• br Conclusion br Authors contribution br

  2019-05-06

  

  Conclusion Authors’ contribution Competing interests Acknowledgments Case report Imatinib has radically changed prognosis in chronic-phase Chronic Myeloid Leukemia (CML), with 90% overall survival rate at 8yrs, and 40–70% of patients achieving a stable MMR [1]. Even better results hav

• Interpretation Stakeholders from sectors not historically en

  2019-05-06

  

  Interpretation Stakeholders from sectors not historically engaged in health care are forming unique partnerships with common goals and a willingness to address the challenge of global cancer care. Funding None. Declaration of interests Abstract Background Since 2013 medical students from North

• Our research in this area has been

  2019-05-06

  

  Our research in this area has been focused on understanding the highly vascular nature of RCC, which has been largely attributed to loss of function of the von Hippel-Lindau (VHL) gene and resultant vascular endothelial growth factor (VEGF) over-expression, as it is an early event during tumorgenesi

• br Methods br Results br

  2019-05-05

  

  Methods Results Discussion A. baumannii remains one of the most common nosocomial pathogens and frequent causes of outbreaks in burn wound infections. Unfortunately, most of the isolates are resistant to antimicrobial agents. β-Lactamases are microbial enzymes that hydrolytically inactivate

• Amongst other anti arrhythmic medications disopyramide class

  2019-05-05

  

  Amongst other anti-arrhythmic medications, disopyramide (class 1A AAM) has anticholinergic side effects such as dry mouth, urinary hesitancy, constipation and exacerbation of conditions like glaucoma and myasthenia gravis. Disopyramide acts by targeting the fast sodium erk pathway in the cardiac ti

• order OG-L002 En ese encuentro de intereses entre los distin

  2019-05-05

  

  En ese encuentro de intereses entre los distintos grupos, bien sea por dominar el territorio, o por imponer la fuerza, o bien por controlar el negocio del narcotráfico, la población queda expuesta y vulnerable. Los ataques entre unos y otros tienen serias repercusiones sobre los poblados “las accion

• br Results br Discussion Atrial fibrillation is widely recog

  2019-05-04

  

  Results Discussion Atrial fibrillation is widely recognized as the most common sustained arrhythmia. The risk of AF development may be determined by evaluating the patients’ age, sex, underlying Axitinib disease, other medical illnesses, and echocardiographic findings. However, better predicto

• br Discussion The present meta analysis of randomized trials

  2019-05-04

  

  Discussion The present meta-analysis of randomized trials demonstrated that treatment with AAMs is associated with an increase in non-cardiac and all-cause mortality as compared to non-arrhythmic therapy or control group. There was no significant reduction in cardiac or arrhythmic mortality betwe

• br Genetic basis for atrial standstill br Genetic

  2019-05-04

  

  Genetic basis for atrial standstill Genetic basis of conduction block Genes involved in cardiac development and bradycardia Development of the CCS is a complex biological process with the potential to be wrought with problems. Several transcription factors, including homeodomain proteins an

• In addition evidence of similar resting HR s

  2019-05-04

  

  In addition, evidence of similar resting HR׳s before exercise in the patients and in the controls implies similar autonomic activity at rest during the daytime in both groups of subjects. In contrast, previous studies have reported changes in the nocturnal HR of BrS patients [3,28]. The discrepancy

• In Blake Alkire and colleagues now

  2019-05-04

  

  In , Blake Alkire and colleagues now provide additional measures to help us gain political priority on the public health agendas. In this study, Alkire and colleagues modelled access to surgery in 180 countries on the basis of four criteria: timeliness, surgical capacity, safety, and affordability.

• Imatinib br In December consecutive waves of major smog shro

  2019-05-04

  

  In December, 2016, consecutive waves of major smog shrouded China, particularly the North China Plain and Sichuan Basin, resulting in suspended schools, halted industrial production, and heavy traffic. Atmospheric levels of fine particulate Imatinib (PM) spiked to more than 500 μg/m in Henan and

• Accordingly blockade of TL A Fas L TLR cascades and

  2019-05-04

  

  Accordingly, blockade of TL1A/Fas-L/TLR4 cascades and inhibition of the M1/Th1 differentiation associated with DcR3 might potentially rescue hepatic IR injury. However, the contribution of TL1A/Fas-L/TLR4 on the M1/M2 and Th1/Th2 balances, as well as pathogenic liver IR injury had never previously b

• br A new model of human wellbeing is emerging

  2019-04-30

  

  A new model of human wellbeing is emerging to guide humanity in the Anthropocene. In essence, it recognises that wellbeing depends on enabling every person to lead a life of dignity and opportunity, while safeguarding the integrity of Earth\'s life-supporting systems. The conceptual framework of s

• We also thank Kate Mandeville and Adamson Muula for

  2019-04-30

  

  We also thank Kate Mandeville and Adamson Muula for their letter and agree with the need to ensure resources are available to fund salaries for newly trained doctors and other health workers to allow these workers to be absorbed into the under-resourced Malawian health system. The doctors\' salary c

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