• br Acknowledgments This work was funded

  2018-10-24

  

  Acknowledgments This work was funded by operating grants to C.M.M. from the Canadian Institutes of Health Research (CIHR) (CIHR-NCE - 72041182) and the Heart and Stroke Foundation of Canada (H&S - 72043144). A.C. is a recipient of the Ontario Graduate Scholarship award. Introduction Neural st

• carboxypeptidase br The NHP for transplantation therapy addr

  2018-10-24

  

  The NHP for transplantation therapy: addressing the graft location An important aspect of successful cell transplantation therapy for PD is the restoration of the complete physiological neuronal network (Gaillard and Jaber, 2011; Shinoyama et al., 2013). The standard protocol for transplanting do

• additional reading Another major limitation of the adult car

  2018-10-24

  

  Another major limitation of the adult cardiac stem cell field is the inability to get full differentiation from putative stem/progenitor additional reading in vitro or in vivo. In fact, although expression of cardiac genes and proteins is demonstrated frequently, the levels, relative to authentic CM

• br Experimental Procedures br Acknowledgments

  2018-10-24

  

  Experimental Procedures Acknowledgments Introduction New neurons are continuously generated in the hippocampal dentate gyrus (DG) throughout life in mammals, including rodents (Altman and Das, 1965; Kaplan and Hinds, 1977; Kuhn et al., 1996), nonhuman primates (Gould et al., 1999; Kornack a

• Our results suggest several open questions that will

  2018-10-24

  

  Our results suggest several open questions that will require further investigation. Although evidence suggests that eradication of cancer stem micromolar to molar appears to be beneficial for curing cancers, recent studies also suggest that noncancer stem cells acquire a cancer stem cell phenotype

• br Results br Discussion We have developed an automated segm

  2018-10-24

  

  Results Discussion We have developed an automated segmentation, classification, and localization measurement algorithm (Figure 7A) for analysis of confocal and two-photon microscopy images of HSCs, osteoblasts, and bone obtained through intravital microscopy of mouse bone marrow. In particular

• In this study we transplanted human

  2018-10-24

  

  In this study, we transplanted human iHeps into the livers of Gunn rats. Proliferation of the transplanted stavudine was induced by preconditioning a single liver lobe by hepatic X-irradiation (HIR). HIR enhances the engraftment of transplanted cells by transiently disrupting the sinusoidal endothe

• Several previous studies support the possibility

  2018-10-24

  

  Several previous studies support the possibility that RPC differentiation into podocytes may be involved in remission of different types of diseases, including proliferative glomerulonephritis (Rizzo et al., 2013), gestational pre-eclampsia (Penning et al., 2014), and diabetic nephropathy (Pichaiwon

• In order to understand how hematopoiesis

  2018-10-24

  

  In order to understand how hematopoiesis is regulated, it is necessary not only to understand the different signals emanating from the niche (Anthony and Link, 2014), but also to comprehend the integration of these signals by HSCs. Canonical Wnt signaling has been related to the regulation of HSCs

• Nishi et al a b have developed a method

  2018-10-24

  

  Nishi et al. (2014a, 2014b) have developed a method of inducing cancer stem-like Phos-tag (CSCs) through the reprogramming and partial differentiation of the immortalized but otherwise normal MCF10A human mammary epithelial cell line. To experimentally test our computational model of oncometabolic

• br Experimental Procedures br Author

  2018-10-24

  

  Experimental Procedures Author Contributions All authors fulfill the ICMJE guidelines for authorship. E.B.B., Y.L.T., Y.P.P., S.L., H.S.C., Q.D., and S.-B.J. performed the biological experiments. Y.L.T. and D.R. performed the bioinformatics part of the study. A.L., X.L., C.S., S.-B.J., and U.L

• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Introduction Frontotemporal dementia (FTD) refers to a group of neurodegenerative diseases caused by focal but progressive neuronal loss, astrogliosis, and spongiosis in the frontal and temporal cortices associated with abnormal intracellular acc

• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Introduction Frontotemporal dementia (FTD) refers to a group of neurodegenerative diseases caused by focal but progressive neuronal loss, astrogliosis, and spongiosis in the frontal and temporal cortices associated with abnormal intracellular acc

• In this article we searched for genes that

  2018-10-24

  

  In this article, we searched for genes that are induced by KLF4 in a dose-dependent manner and identified Tcl1 as its direct target. KLF4 induces Tcl1 transcription during reprogramming via direct binding to its enhancer and promoter regions, concurrently changing repressive histone marks into activ

• Here we report that FH iHeps derived

  2018-10-24

  

  Here, we report that FH iHeps derived from patient-specific and genetically engineered FH iPSCs can be used to test the efficacy of two well-known medications for lowering LDL-C, statins and PCSK9 antibodies, not only in vitro but also in vivo, by engrafting FH iHeps into the liver of immunodeficien

15532 records 1031/1036 page Previous Next First page 上5页 10311032103310341035 下5页 Last page