• Therefore in the present study we first examined the

  2024-01-08

  

  Therefore, in the present study, we first examined the ATRAP Betaine receptor in human leukocytes of healthy subjects. We next analyzed possible relevant clinical factors affecting ATRAP expression in leukocytes of patients with NCDs. Furthermore, we examined the possible effect of ATRAP downregula

• Several ceritinib resistant mutations following the second

  2024-01-05

  

  Several ceritinib-resistant mutations following the second-line treatment of ALK+-NSCLC have been discovered [64]. These mutations include C1156Y, F1174L, and L1152R, which were first observed in crizotinib-resistant tumor samples. The G1202R ceritinib-resistant mutation occurs within the hinge and

• Adenosine is an endogenous nucleoside that plays pivotal

  2024-01-05

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the 3-bromo-5-phenyl Salicylic Acid and in the periphery. The adenosine receptors (ARs) are four different subtypes of G p

• In conclusion we have designed and synthesized a

  2024-01-05

  

  In conclusion, we have designed and synthesized a series of 4-phenyl-thiazole analogues as potent ATX inhibitors. Total twenty-five compounds were synthesized and evaluated for their inhibitory activity on ATX using FS-3 and human plasma assays. Compound was found to be the most potent derivative p

• Analysis of ASK crystal structures as well as

  2024-01-05

  

  Analysis of ASK1 crystal structures as well as an investigation of how UNC 0642 mg 4 might bind were undertaken to understand opportunities for engaging Gln756. To this end a docking model derived from PDB 3VW622 was used to predict the binding mode of amide 4 in the ASK1 active site as shown in Fi

• br Introduction Rhamdia quelen jundi Silurifomes Heptapterid

  2024-01-05

  

  Introduction Rhamdia quelen (jundiá, Silurifomes, Heptapteridae) is a neotropical catfish widely distributed in Central and South America (Silfvergrip, 1996). This species shows high potential for the aquaculture industry, due to an elevated growth rate, good carcass yield, and easy reproduction

• br Introduction Arginase deficiency is a

  2024-01-05

  

  Introduction Arginase deficiency is a rare metabolic disorder resulting from a loss of arginase 1 (ARG1), the final enzyme in the urea cycle, which is the major pathway for the detoxification of ammonia in terrestrial mammals. ARG1 is expressed most prevalently in hepatocytes and red blood cells.

• Mitochondria are key organelles involved in the

  2024-01-05

  

  Mitochondria are key organelles involved in the mechanism of apoptosis (Xiong et al., 2014), and loss of ΔΨm is an important marker associated with mitochondrial dysfunction and cell death. We found that Mino induced ΔΨm impairment and nuclear fragmentation in Jurkat TCEP in a concentration-dependen

• Patients with cardiovascular disorders typically have lower

  2024-01-05

  

  Patients with cardiovascular disorders typically have lower plasma apelin levels than matched healthy controls. For example, plasma apelin levels are reduced in patients with coronary artery disease (CAD), and among CAD patients with unstable angina or acute myocardial infraction there is a further

• Later on Wayner Burton Ingold Barclay and Locke modified

  2024-01-04

  

  Later on, Wayner, Burton, Ingold, Barclay, and Locke (1987) modified the method by using lipid to examine the ability of an antioxidant Eosin Y protect against lipid peroxidation generated by azo-compound. It was later improved using β-phycoerythrin (β-PE) as a fluorescent probe, and the ability of

• Several strategies have been employed to

  2024-01-04

  

  Several strategies have been employed to design and engineer peptide biosensors of kinase activity, which are quite different from the strategies developed to generate genetically encoded KARs. In all cases, MHC class II antigen (45-57) [Homo sapiens] induces changes in the spectral properties of th

• br Nanoparticle Conjugated Topoisomerase Inhibitors The safe

  2024-01-04

  

  Nanoparticle-Conjugated Topoisomerase Inhibitors The safety and efficacy of topotecan administered as LDM or MTD have been evaluated in several preclinical studies and a few clinical trials whose results showed that there can be significant adverse effects likely precluding its use in patients [5

• TRAM-34 Platelet derived growth factor PDGF

  2024-01-04

  

  Platelet-derived growth factor (PDGF) and ciliary neurotrophic factor (CNTF) are expressed by glial TRAM-34 and are important to neuron survival and the maintenance of oligodendrocytes. These neurotrophic factors contribute to the remyelination process by increasing the proliferation of oligodendroc

• The correlation in the increase of BADH

  2024-01-04

  

  The correlation in the increase of BADH mRNA, protein levels, and enzyme activity, demonstrate that oxidation of betaine aldehyde by BADH is primordial to regulate the GB accumulation during physiological cardiac hypertrophy induced by pregnancy, this implies a major role because GB levels enhance c

• br Material and methods br

  2024-01-04

  

  Material and methods Results Discussion Clinical gene therapy trials with viral vectors have been in use for treatment of various genetic disorders and diseases, however efficacious, targetable and highly reliable non-viral delivery systems are needed for safe and long-term applications. De

16176 records 205/1079 page Previous Next First page 上5页 201202203204205 下5页 Last page