• In order to understand how hematopoiesis

  2018-10-24

  

  In order to understand how hematopoiesis is regulated, it is necessary not only to understand the different signals emanating from the niche (Anthony and Link, 2014), but also to comprehend the integration of these signals by HSCs. Canonical Wnt signaling has been related to the regulation of HSCs

• Nishi et al a b have developed a method

  2018-10-24

  

  Nishi et al. (2014a, 2014b) have developed a method of inducing cancer stem-like Phos-tag (CSCs) through the reprogramming and partial differentiation of the immortalized but otherwise normal MCF10A human mammary epithelial cell line. To experimentally test our computational model of oncometabolic

• br Experimental Procedures br Author

  2018-10-24

  

  Experimental Procedures Author Contributions All authors fulfill the ICMJE guidelines for authorship. E.B.B., Y.L.T., Y.P.P., S.L., H.S.C., Q.D., and S.-B.J. performed the biological experiments. Y.L.T. and D.R. performed the bioinformatics part of the study. A.L., X.L., C.S., S.-B.J., and U.L

• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Introduction Frontotemporal dementia (FTD) refers to a group of neurodegenerative diseases caused by focal but progressive neuronal loss, astrogliosis, and spongiosis in the frontal and temporal cortices associated with abnormal intracellular acc

• br Experimental Procedures br Author Contributions br

  2018-10-24

  

  Experimental Procedures Author Contributions Introduction Frontotemporal dementia (FTD) refers to a group of neurodegenerative diseases caused by focal but progressive neuronal loss, astrogliosis, and spongiosis in the frontal and temporal cortices associated with abnormal intracellular acc

• In this article we searched for genes that

  2018-10-24

  

  In this article, we searched for genes that are induced by KLF4 in a dose-dependent manner and identified Tcl1 as its direct target. KLF4 induces Tcl1 transcription during reprogramming via direct binding to its enhancer and promoter regions, concurrently changing repressive histone marks into activ

• Here we report that FH iHeps derived

  2018-10-24

  

  Here, we report that FH iHeps derived from patient-specific and genetically engineered FH iPSCs can be used to test the efficacy of two well-known medications for lowering LDL-C, statins and PCSK9 antibodies, not only in vitro but also in vivo, by engrafting FH iHeps into the liver of immunodeficien

• To further explore the value of feline liver

  2018-10-24

  

  To further explore the value of feline liver organoids as a research model for steatosis, we tested the effect of small molecules on lipid metabolism. Lipid accumulation was enhanced in the presence of etomoxir, indicating that β-oxidation is an important metabolic pathway handling excess fatty acid

• Our work extends these efforts by directly targeting transge

  2018-10-24

  

  Our work extends these efforts by directly targeting transgenes to inducible, endogenous loci using the efficient and highly specific CRISPR/Cas9 genome-engineering technology (Maeder and Gersbach, 2016; Jinek et al., 2012). In this manner, our strategy forgoes limitations associated with predicting

• As mentioned above the region

  2018-10-24

  

  As mentioned above, the region of the piezomaterial was discretized by 8-node Plane223 elements. Each node of such an Aprotinin had three degrees of freedom: for the displacements along the OX axis, for the displacements along the OY axis, and the electric potential U allowing to solve the equations

• br Conclusion br Acknowledgements The

  2018-10-24

  

  Conclusion Acknowledgements The authors would like to thank the funders of this project, the Canadian Institute of Health Research (CIHR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Introduction Evidence fro

• Together these findings demonstrate the benefit of

  2018-10-24

  

  Together these findings demonstrate the benefit of simultaneous analysis in elucidating potential pathways between the environment and activity, by ensuring that significant relationships are not obscured by unaccounted for aspects of the environment. However, few studies used interaction or mediati

• Historical and social contexts are important to the educatio

  2018-10-24

  

  Historical and social contexts are important to the education-mortality association (Hayward, Hummer & Sasson, 2015), and the family influence on this relationship may also be context dependent. As a consequence, the interplay between family, education, and health outcomes may change over time. Howe

• Age adjusted odds ratios AOR of morbid obesity

  2018-10-24

  

  Age-adjusted odds ratios (AOR) of morbid obesity by income and by education are presented in Tables 2 and 3. These estimates confirm a graded association of morbid obesity with income and education category in both English men and women. In the lowest category of income, compared with the highest, t

• Introduction One of the key drivers of performance of

  2018-10-24

  

  Introduction One of the key drivers of performance of salespeople was long ago speculated to be ego-drive (Mayer & Greenberg, 1964). Ego-drive has not been studied systematically in marketing and has been defined in various ways, referring to motivation, a “need to conquer”, and pride. We attempt i

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